Ahmed Kasem Mohamed Zain Eldin
Lecturer
Evaluation of pregnancy outcome in cases of intrauterine growth restriction in relation to placenta apoptosis and doppler indices of the umbilical and uterine arteries
• 2021
Publication Information
Authors
Ahmed Kasem Mohamed Zain Eldin , Ahmed Sabra Ibrahim Mohammed Sabra , Aziza Ali Elsayed Negm
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publication.type
Local
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Abstract
Objective: To assess apoptotic changes in trophoblastic cells in normal term placentae and term placentae complicated by either preeclampsia or intrauterine growth restriction (IUGR). Additionally, we aim to examine the correlation between these apoptotic changes and the Doppler velocity of the umbilical and uterine arteries. Methods: This prospective observational study was conducted on 150 pregnant women, including 100 cases with preeclampsia and 50 controls. Placentas were collected at delivery, and apoptotic changes were examined using light microscopy and immunohistochemical staining. Doppler velocimetries were performed to assess umbilical and uterine artery resistance indices. Pregnancy outcomes and neonatal data were recorded. Results: The incidence of apoptosis in placentae was significantly higher in the preeclampsia group compared to the control group (p