Amira Osama Abd El-Ghafar
Asst. Professor
Value of Interleukin 6 in Assessment of the Disease Severity in Patients with COVID-19 Infection without Preexisting Comorbidities
Benha Medical Journal • 2023
Publication Information
Authors
Amany H. Lashin a, Amira O. Abd El-Ghafarb, Ahmed M. Mahmouda, Mohammad E. El Shewi a
Keywords
Interleukin 6; COVID-19; Severity; Comorbidities
a Department of Hepatology, Gastroenterology, and Infectious diseases, Faculty of Medicine Benha University, Egypt. b Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University Corresponding to: Ahmed M. Mahmoud, Department of Hepatology, Gastroenterology, and Infectious diseases, Faculty of Medicine Benha University, Egypt. Email: ahmedmahmdadel@gmail.com Received:3 January 2023 Accepted:19 February 2023 Print ISSN 1110-208X Online ISSN 2357-0016
Journal
Benha Medical Journal
Publisher
Benha University, Faculty of Medicine
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: In December of 2019, Wuhan, a new coronavirus-caused pandemic of atypical pneumonia was reported by China. This study determined IL-6 value in disease severity assessment of COVID-19 patients without preexisting pathologies. Methods: This cross-sectional study was conducted on 100 participants. They were classified into group A included 25 patients classified as mild or moderate cases, group B included 25 patients classified as severe cases, group C included 25 patients classified as critical ill cases and all was positive PCR COVID-19 and group D (Control Group) included 25 healthy individuals. Participants were subjected to history taking, Serum IL-6 measurement using ELISA, laboratory investigations and imaging. Results: IL-6 significantly differed between the studied groups (P < 0.001). IL-6 showed significant positive correlations with age (r = 0.338, P = 0.003), SBP (r = 0.288, P = 0.012), temperature (r = 0.262, P = 0.023), respiratory rate (r = 0.729, P < 0.001), D-dimer (r = 0.704, P < 0.001), ferritin (r = 0.791, P < 0.001), CRP (r = 0.592, P < 0.001), and severity (r = 0.821, P < 0.001). Multinomial logistic regression analysis revealed that IL-6 was a significant predictor for mild to moderate covid (OR = 7.66, 95% CI = 2.212 – 26.528, P = 0.001), severe covid (OR = 17.727, 95% CI = 4.545 – 69.141, P < 0.001), and critically ill patients (OR = 24.345, 95% CI = 6.135-96.604, P < 0.001). Conclusion: IL-6 can significantly predict COVID-19 severity (mild to moderate, severe and critically ill) and mortality.