Abstract
Polycystic Ovary Syndrome (PCOS) is one of the most frequent conditions, which affects both metabolic and reproductive systems causing irregular menstrual cycles, chronic anovulation, and hyper-androgenism. The beneficial effects of Cinnamon zeylanicum (CZ) Hydroalcoholic extract on oxidative injury and hormonal alterations in adult rats with PCOS were evaluated. PCOS was induced by administration of letrozole (1mg/kg b. wt. /day, orally) for 4 weeks. Four weeks after PCOS induction, treatment with Metformin (150mg/kg b. wt./day) and Cinnamon zeylanicum (CZ) Hydroalcoholic extract (200mg/kg b. wt./day), orally were started and continued for 30 days. Fifty female rats were equally divided into 5 groups. Group I (Normal control): Rats received Rats received no drugs, Group II (letrozole-induced PCOS): Rats were orally administrated 1mg/kg b. wt. /day of letrozole for 4 weeks, Group III (Metformin treated): After 4 weeks of letrozole administration, rats were orally treated with 150mg/kg b. wt./day of metformin for 30 days, Group IV (CZ treated): Rats were administrated letrozole as group II and orally treated with 200mg/kg b. wt./day of Hydroalcoholic extract of CZ for 30 days, Group V (metformin + CZ treated): Rats were administrated letrozole and treated daily with metformin and CZ for 30 days as group III+IV. The results revealed a significant decrease in serum estrogen, progesterone and antioxidant markers with marked elevations in serum MDA, total cholesterol and triacylglycerol concentrations in PCOS as compared with normal control group. However, treatment with Hydroalcoholic extract of CZ or/and Metformin to PCOS rats caused remarkable ameliorations in all previous parameters.
Conclusively, the Hydroalcoholic extract of CZ treatment ameliorates oxidative injury caused by letrozole enhances the antioxidant defense system, and prevents lipid peroxidation.