The present work aims to study the potential effect of aqueous leaves extract Moringa oleifera (MO) on male albino rats treated orally with diclofenac sodium (DcNa). Forty-five male albino rats were used and randomly divided into 5 groups as follows: group I "normal group", group II "DcNa group", group III "MO group", group IV "DcNa then MO group" and group V "MO then DcNa group". Treatment with DcNa showed a significant decrease in body weight while caused significant increases in relative organs weight (liver, kidney, spleen and brain). Moringa oleifera caused a significant increase in body weight while showed non-significant decreases in relative organs weight (liver, kidney and spleen). DcNa exhibited significant decreases in WBCs count, lymphocytes % and neutrophil % while caused a significant increase in monocyte %. Also, there were non-significant increase and decrease in eosinophil % and basophil % respectively. Treatment with MO showed non-significant increases in white blood cell count, monocyte % and neutrophil % while showed non-significant decrease in lymphocyte %. Eosinophil % and basophil % were increased significantly. Administration of DcNa caused significant decreases in serum total protein, albumin and globulin levels. Treatment with Moringa oleifera showed a significant increase in serum albumin level while showed non-significant increases in serum total protein and globulin levels.
The present study suggests that Moringa oleifera is useful in maintaining the harmful effect of diclofenac sodium in male albino rats.