Virtual reality (VR) is an innovative technology and a computer-generated three-dimensional simulation that is associated with high empirical realism. It provides a vast range of sensory information to the user to interact with objects in a virtual environment and can be used to encourage nursing students develop skills in virtual hospital settings. Aim of the study was to evaluate the effect of virtual reality as a teaching strategy on pediatric nursing students’ performance regarding cardiopulmonary resuscitation. Study design: An experimental design (study & control groups/ pre-posttest) was utilized. Setting: The pediatric nursing skills laboratory for third year/ Faculty of Nursing/ Benha University. Study subjects: A systematic random sample of (62) pediatric nursing students was selected from the pediatric nursing students who were studying the pediatric nursing course/third year/second semester during the academic year 2222/2223. Tools of data collection: Three tools were used; Tool I: A structured interviewing questionnaire, Tool II: Student's clinical evaluation checklist (pre/posttest) and Tool III: Virtual reality–teaching material usability questionnaire (posttest). Results: Vast majority of nursing students in study group had good knowledge level post-implementation compared with one third in control group. Also, majority of nursing students in the study group had competent total practices level regarding CPR post-implementation compared with more than half in the control group. Furthermore, vast majority of the nursing students in the study group had positive opinion about virtual reality-teaching material usability post-implementation. Conclusion: Virtual reality as a teaching strategy was effective in improving knowledge and enhancing practices of pediatric nursing students regarding CPR. Recommendations: Integrating virtual reality technology in nursing clinical courses to reinforce their performance in clinical settings