عبير محمد راوى عبد المنعم
أستاذ
CO-RADS score and its correlation with clinical and laboratory parameters in patients with COVID-19
The Egyptian Journal of Bronchology • 2023
معلومات البحث
المؤلفون
Marwa Elsayed Elnaggar1* , Abeer Mohamed Rawy1, Marwa Seif El‑Melouk2, Al‑Shaimaa Mahmoud Al‑Tabbakh2, Hamasat Abdel‑hafeez Abdel‑Khalik3, Eman Fathy Abdelkhalek4 and Rehab Elsayed Elsawy
الكلمات المفتاحية
Not Available
المجلة العلمية
The Egyptian Journal of Bronchology
الناشر
Not Available
المجلد
Not Available
العدد
Not Available
الصفحات
Not Available
publication.type
Local
رابط البحث
Not Available
المواد المرفقة
Abeer Mohamed Rawy Abdel- Monem_paper 3.pdf
الملخص
Abstract
Background Polymerase chain reaction (PCR) based SARS-CoV-2 RNA detection and serological antibody tests giv
a proof of Coronavirus Disease 2019 (COVID-19) infection. Several variables can infuence the consequences of these
tests. Infammatory markers among mild and severe patients of COVID-19 showed dissimilarity in infammatory mark
ers while computed tomography (CT) in patients infected with COVID-19 used to evaluate infection severity. The aim
of this study is to investigate the application of the COVID-19 Reporting and Data System (CO-RADS) classifcation i
COVID-19 patients and its relation to clinical and laboratory fnding
Results One hundred patients suspected to have COVID-19 infection were involved. Their age was 49.6 ± 14.7. Fever
and cough were the frequent presenting symptoms. Patients with positive PCR were signifcantly associated with
dyspnea and higher infammatory markers. Lymphopenia had sensitivity of 63.6% and specifcity of 91.7%. Combina‑
tion of PCR and lymphopenia increased both sensitivity and specifcity. CT fndings in relation to PCR showed sensitiv‑
ity of 90.5% and specifcity of 25%. CO-RADS score showed positive correlation with age and infammatory biomarkers
and negative correlation with absolute lymphocyte count (ALC).
Conclusions CT fnding was more prominent in older patients with COVID-19 and associated with higher infam
matory biomarkers and lower ALC which were correlated with CO-RADS score. Patients with positive PCR had more
symptoms and infammatory marker. Combination of PCR with either lymphopenia or CT fnding had more sensitivity,
specifcity and accuracy in diagnosis
Background Polymerase chain reaction (PCR) based SARS-CoV-2 RNA detection and serological antibody tests giv
a proof of Coronavirus Disease 2019 (COVID-19) infection. Several variables can infuence the consequences of these
tests. Infammatory markers among mild and severe patients of COVID-19 showed dissimilarity in infammatory mark
ers while computed tomography (CT) in patients infected with COVID-19 used to evaluate infection severity. The aim
of this study is to investigate the application of the COVID-19 Reporting and Data System (CO-RADS) classifcation i
COVID-19 patients and its relation to clinical and laboratory fnding
Results One hundred patients suspected to have COVID-19 infection were involved. Their age was 49.6 ± 14.7. Fever
and cough were the frequent presenting symptoms. Patients with positive PCR were signifcantly associated with
dyspnea and higher infammatory markers. Lymphopenia had sensitivity of 63.6% and specifcity of 91.7%. Combina‑
tion of PCR and lymphopenia increased both sensitivity and specifcity. CT fndings in relation to PCR showed sensitiv‑
ity of 90.5% and specifcity of 25%. CO-RADS score showed positive correlation with age and infammatory biomarkers
and negative correlation with absolute lymphocyte count (ALC).
Conclusions CT fnding was more prominent in older patients with COVID-19 and associated with higher infam
matory biomarkers and lower ALC which were correlated with CO-RADS score. Patients with positive PCR had more
symptoms and infammatory marker. Combination of PCR with either lymphopenia or CT fnding had more sensitivity,
specifcity and accuracy in diagnosis