Abstract
Background: There is still a clinical challenge in differentiating between malignant pleural effusion (MPE) and benign pleural effusion (BPE). Aim: to evaluate the role of microRNA (182) in differentiation between tuberculous (TPE) and MPE. Methods: This cross-sectional study involved 60 patients admitted to the Chest Department, Benha University Hospital. Patients were divided into two groups based on pathology results: Group A (n=45): MPE and Group B: (n=15): TPE. miRNA 182 was measured by qt PCR in both groups and expressed as ΔΔCT and fold change(2-ΔΔCt ) Results: No statistically significant difference between MPE and TPE regarding ΔΔCT and fold change and the level did not differ significantly between malignant types. Adenosine deaminase (ADA) can significantly differentiate between malignant and TB groups (P