Ahmed Mohamed Hamed Mahmod
Professor
Unraveling the relation between vitiligo, Interleukin 17, and serum amyloid A
• 2022
Publication Information
Authors
Aliaa Abd Elsalam Ahmed MSc1 | Nancy Wadie Mikhael MD1 | Asmaa Adel Elfallah MD2 |
Ahmed Mohammed Hamed
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Abstract
Background: There is debate concerning the precise etiopathogenesis of vitiligo.
According to certain theories, a series of inflammatory responses that mediate the
loss of melanocytes are caused by both cellular and humoral immune responses. It has
also been demonstrated that Interleukin 17 (IL-17)
promotes melanocyte death and
inhibits melanogenesis through different mechanisms. Serum Amyloid A (SAA) levels
are over-expressed
in autoimmune diseases. Th17 cytokines are regulated by serum
amyloid A proteins.
Aims: To measure serum levels of IL-17
and SAA in vitiligo patients aiming to explain
their possible role in disease pathogenesis and the other aim is to correlate their levels
with disease activity and severity.
Methods: This study included 60 vitiligo patients and 40 healthy age and sex controls.
Enzyme-linked
immunosorbent assay was used to measure serum levels of SAA and
IL-17.
Results: This study revealed significant increase in levels of serum IL-17
and SAA in
patients than controls (p < 0.05). Both markers showed significant positive correlations
with VASI score and duration of vitiligo; only IL-17
showed statistically significant
positive correlation with VIDA scores. Patients with vitiligo showed a statistically
significant positive connection between serum IL-17
levels and SAA (γ = 0.992, p-value
Background: There is debate concerning the precise etiopathogenesis of vitiligo.
According to certain theories, a series of inflammatory responses that mediate the
loss of melanocytes are caused by both cellular and humoral immune responses. It has
also been demonstrated that Interleukin 17 (IL-17)
promotes melanocyte death and
inhibits melanogenesis through different mechanisms. Serum Amyloid A (SAA) levels
are over-expressed
in autoimmune diseases. Th17 cytokines are regulated by serum
amyloid A proteins.
Aims: To measure serum levels of IL-17
and SAA in vitiligo patients aiming to explain
their possible role in disease pathogenesis and the other aim is to correlate their levels
with disease activity and severity.
Methods: This study included 60 vitiligo patients and 40 healthy age and sex controls.
Enzyme-linked
immunosorbent assay was used to measure serum levels of SAA and
IL-17.
Results: This study revealed significant increase in levels of serum IL-17
and SAA in
patients than controls (p < 0.05). Both markers showed significant positive correlations
with VASI score and duration of vitiligo; only IL-17
showed statistically significant
positive correlation with VIDA scores. Patients with vitiligo showed a statistically
significant positive connection between serum IL-17
levels and SAA (γ = 0.992, p-value