Background: Cesarean delivery is the most common inpatient surgical procedure performed worldwide; improving the peri-operative care of parturient has significant global implications. This study aimed to compare Ketorolac versus Nefopam when administered intravenously with Tramadol during induction of anesthesia as post-operative analgesia over a 24 hours period following surgery in patients who undergo cesarean section. Methods: This prospective randomized study was conducted on 100 female patients with American Society of Anesthesiolbogists (ASA) classification II. Patients were randomly allocated into two equal groups: group N: received slow intravenous administration of Nefopam. Group K: received slow intravenous administration of Ketorolac. Results: The time of the 1st rescue analgesic requirement was significantly delayed in group N compared to Group K (P