Background: Caregivers of children with ADHD often experience stress and anxiety because of increasing demands of the child condition. These challenges contribute to a heavy feeling of burden and reduce psychological capital of them. As a result, their psychological capital may decline over time. Aim: This study aimed to assess relationship between feeling of burden and psychological capital among caregivers of children with attention deficit hyperactivity disorder. Research design: A descriptive correlational research design was utilized to achieve the aim of the study. Setting: The study was conducted at the children outpatient clinics at Psychiatric and Mental Health Hospital and Addiction Treatment at Benha city, Qalubia governorate which is affiliated to General Secretariat of mental health. Subject: A purposive sample of (60) caregivers of children with ADHD was utilized in this study. Tools: Three tools were used for data collection: Tool (1): - A- structured interviewing questionnaire sheet included socio- demographic data of studied caregivers, socio- demographic and clinical data of the affected children as well as caregivers' knowledge about ADHD. Tool (2):- Zarit burden interview scale & Tool (3):- Psychological capital questionnaire. Results: The result of the present study revealed that one quarter of the studied caregivers who have satisfactory level of total knowledge about ADHD and more than half of the studied caregivers experience moderate burden. Also, the minority of the studied caregivers have high level of psychological capital. Conclusion: there is highly statistically significant negative correlation between total burden and total knowledge and total psychological capital mean scores among caregivers of children with ADHD Recommendations: psycho-educational nursing programs should be applied as an immediate measure for all caregivers of children with ADHD in all hospitals to improve their psychological capital and hence reduce their feeling of burden.