Background: Ensuring patient safety is a fundamental aspect of healthcare delivery across all settings.
Identifying any deficiencies in care and enhancing nurses' awareness of their pivotal role are critical in
saving patients' lives. This study aims to assess the impact of an intervention protocol focused on
safety measures, with a focus on knowledge, practices, and attitudes of nurses caring for patients
undergoing cardiac catheterization. Design: A quasi-experimental research design with a pre/post-test
approach was employed for this study. Setting: The study was conducted within the cardiac
catheterization unit at Benha University Hospital, which is affiliated with Benha University, located in
Qualyubia Governorate, Egypt. Sample: A convenience sample of 40 cardiac nurses of both genders
was included in the study. Tools: Three distinct tools were employed: I. A structured interview
questionnaire to assess nurses' knowledge concerning safety measures. II. A safety measures
observational checklist to evaluate nurses' practical implementation of safety measures. III. A safety
attitude questionnaire to gauge nurses' overall attitude towards safety. Results: Following the
implementation of the intervention protocol, significant positive outcomes were observed: A highly
statistically significant correlation between total knowledge and attitude among the studied nurses (p ≤
0.001). A statistically significant correlation between total practices, total knowledge, and attitude
among the studied nurses (p ≤ 0.05). Conclusion: The study's findings indicate a substantial
improvement in nurses' overall knowledge, practices, and attitude concerning cardiac catheterization
and safety measures immediately post-intervention protocol. Recommendations: To uphold patient
safety and quality care, it is recommended that nurses working in cardiac catheterization units actively
engage in continuous educational and training programs. These initiatives are crucial for updating
nurses' knowledge and enhancing their practical skills with respect to safety measures concepts. Such
ongoing professional development ensures that nurses remain current and competent in providing safe
care for patients undergoing cardiac catheterization.