Titanium oxide (TiO2) was fabricated by using an auto-combustion technique with albumin egg fuel followed by calcination at 600 degrees C for half an hour. TiO2 nanoparticles were characterized by using various tools such as thermogravimetric analysis and differential thermal analysis, X-ray diffraction, energy dispersive X-ray analysis, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The synthesized TiO2 used as an adsorbent for Pb2+ removal from water. The removal of Pb2+ from water and adsorption capacity of the calcined TiO2 nanoparticles was examined at different parameters. The model of adsorption isotherm and adsorption kinetics are used for the description of the removal of leads ions over the calcined TiO2 nanoparticles.