Background: Non-alcoholic fatty liver disease (NAFLD) is
rapidly becoming one of the most common causes of chronic
liver disease worldwide. The biopsy is the gold standard tool
for disease diagnosis, but it is usually not accepted by the
patients due to its invasive nature. The use of non-invasive
biomarkers is now attaining a great interest in diagnosis and
detection of the disease severity.
Aim of the work: Investigate the role of fetuin A in diagnosis
and assessment of severity of non-alcoholic fatty liver disease
(NAFLD). Subjects and methods: This cross sectional study
included 50 patients with NAFLD and 50 healthy control
subjects. All cases were subjected to history taking, clinical
examination and laboratory investigation (including
assessment of fetuin A), abdominal ultrasonography and
fibroscan with controlled attenuated parameter (CAP scan).
Results: The level of fetuin A was statistically significantly
higher in the cases group as compared with the control group
(1154.85±629.89 and 505.29±150.4 respectively) (p < 0.001).
Fetuin-A had significant validity in prediction of NAFLD at
cut off >702.5 with sensitivity 82%, specificity 90% and
accuracy 86%. Also, the marker was related to disease severity
as it revealed a significant correlation with ultrasound grading
(p