Royal Jelly (RJ) is a natural product made by nurse bees known for its multiple therapeutic properties. The
research aims to discover the ability of RJ to improve the hematological alterations and neurotoxicity caused by
acrylamide (AA). The study rats were separated equally into four groups (6 in each group), the control group, the
AA (38.27 mg/kg bw) group, the RJ (150 mg/kg bw) + AA group, and the RJ (300 mg/kg bw) + AA group. Blood
and brain samples were collected after 10 days to evaluate haematological and biochemical parameters and to
examine histopathological and immunohistochemistry. The administration of AA increased the level of malondialdehyde
(MDA), decreases levels of haematological parameters, superoxide dismutase (SOD), reduced
glutathione (GSH), brain-derived neurotrophic factor (BDNF), neurotransmitters (serotonin, dopamine, and
acetylcholine), and cleaved caspase-3, as well as increase the damage to the brain tissues. Meanwhile, RJ
improved levels of haematological parameters, oxidative stress parameters (MDA, SOD, and GSH), BDNF, neurotransmitters,
cleaved caspase-3, and brain tissue damage induced by AA. The study demonstrated the protective
impact of RJ against the haematological alterations and neurotoxicity caused by AA.