Background: Medical professionals around the world are tasked with the responsibility of graduating well-educated and competent graduate medical student. This desired outcome can be achieved by ensuring satisfactory academic performance and academic success. Aim: is to assess the relationship between academic problems and academic performance among the new integrated system students at Benha Faculty of Medicine. Method: an observational cross-sectional study was conducted on 318 medical students at Benha Faculty of Medicine, using a self-administered questionnaire that consists of socio-demographic, the academic problems facing students and the reasons for the attendance or absence of students' theoretical and practical lecture. Results: Among the academic problems, there were highly statistical significant differences between the studied groups at 2nd, 3rd and 4th levels- regarding academic problems related to professor and academic problems related to courses (P=0.001). Also, there were statistical significant differences between the studied groups at different levels regarding practical part (P=0.003) and academic problems related to equipment (P=0.03). There were highly statistical significant differences between the studied groups achieved different academic performance (GPA) regarding academic problems related to professor (P=0.001), courses (P=0.002) and exams (P=0.01). Regarding the correlation between lecture attendance and academic performance (GPA), there was statistical significant strong positive relationship between theoretical and practical lecture, attendance and academic performance (GPA) (p=0.001). Conclusions: There was statistical significant strong positive relationship between theoretical and practical lecture, attendance and academic performance (GPA).