Background: Epinephrine in liposuction solution mediated vasoconstriction thus decrease in adrenergic side effects, local anesthetic toxicity, and bleeding. The optimum safe adrenaline concentration was not well investigated.
This study aimed to compare adrenaline 1 mg/L and 2 mg/L in tumescent fluid concerning hemodynamics during abdominal liposuction operations.

Methods: Forty cases scheduled for liposuction for abdomen and flanks and body were involved in this randomized, triple-blind, controlled trial. Cases were randomized equally into two groups. Group A (low adrenaline concentration group): received 1 mg per liter of epinephrine. Group B (high adrenaline concentration group): received 2 mg per liter of epinephrine.

Results: Intraoperative heart rate and mean arterial blood pressure at base line were insignificantly different between both groups (p value > 0.05) while at 30, 60, 90, and end of surgery were significantly higher in group B group as opposed to group A (p value < 0.05). Incidence of sinus tachycardia and PVCs were significantly higher in group B than group A (P < 0.05), while surgeon satisfaction was comparable between both groups (p value > 0.05).

Conclusions: In liposuction procedures, the safest adrenaline concentration is 1 mg/L as evidenced by hemodynamics stability and surgeon satisfaction thus even in high volume liposuction, the adrenaline concentration should not exceed 1 mg/L and should be handled to cover the used crystalloid solution