The development of novel multi-target compounds with multiple therapeutic applications represents an excellent strategy for replacing the drug combination approach. Such strategy is beneficial in reducing or preventing the side effects of the combined drugs. Organometallic complexes, particularly those with polymeric structures, demonstrate dual functionality against microbial pathogens and tumor cells. Herein, a new series of polymeric metal complexes with strong antitumor and antimicrobial activity was developed. First, two novel coordination polymers (CP1 and CP2) were synthesized through exchanging the active phthalimidoxy moiety in poly N-methacyloxyphthalimide [poly(NMPI)] with two Schiff base derivatives (S1 and S2). Then, four polymeric metal complexes were constructed by coordinating CP1 and CP2 with copper and nickel acetates, and their chemical compositions were deduced