Introduction: The histological distinction between squamous cell
carcinoma both in-situ and invasive from their benign mimic; irritated
seborrheic keratosis is still a difficulty. The aim of this study is to
investigate the diagnostic utility of Insulin-like growth factor II
mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 )
in differentiating aforementioned cutaneous tumors. Materials and
Methods: This is a retrospective study to include 50 cases, 25(50%)
cases of invasive squamous cell carcinoma (SCC), 10 (20%) cases of
squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of
irritated seborrheic keratosis (ISK). The immunohistochemical
expression of IMP3 and BCL2 was studied (9) Results: BCL2 was
expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in
SCCIS and 4/25 (16%) in invasive SCC cases (p