Background: Liver transplantation operation encompasses a critical period in the patient’s
life which comes with an increase in the risk of poor health outcomes, so self-efficacy plays a
crucial role in shaping self-management behaviors. Aim: This study aimed to evaluate the effect of
applying 5A’s model on self-care efficacy and dependency level among patients with liver
transplantation. Design: A quasi-experimental research design was operated in this study. Setting:
The study was done at the Outpatient Clinic within liver transplantation unit of the National Liver
Institute affiliated to Menoufia University, Egypt. Sample: Purposive sample of 64 patients with
liver transplantation were included. Tools: Three tools were used; I: A structured interviewing
questionnaire to assess patients’ sociodemographic characteristics, previous and current medical
history, knowledge and reported practices toward liver transplantation. II: Barthel index scale to
assess patients’ dependency level in performing activities of daily living. III: Chronic disease self
efficacy scales to assess patients’ self-care efficacy regarding liver transplantation. Results: A
statistically significant difference on the patients’ total levels of knowledge, reported practices,
dependency of activities of daily living activities and self-care efficacy was observed post one and 3
months of 5A’s model application. Conclusion: 5A’s model application raised the studied patients’
total levels of knowledge, reported practices, dependency in performing activities of daily living
and self-care efficacy regarding liver transplantation. Recommendations: Continuous application
of 5A’s model for patients with liver transplantation to enhance their dependency level in
performing activities of daily living and self-care efficacy in different settings.