Tissue engineering has emerged as a transformative field in veterinary medicine, offering innovative solutions for tissue repair, regeneration, and replacement (1). As traditional therapeutic approaches often fail to achieve complete tissue repair or functional restoration, the field has increasingly turned to interdisciplinary strategies that merge tissue engineering, stem cell biology, and biomaterial science (2,3). These innovations not only aim to address the limitations of conventional treatments but also emphasize sustainability, scalability, and translational potential. With the growing demand for advanced therapeutic strategies to address complex injuries, degenerative diseases, and congenital anomalies in animals, the integration of cell-free and cell-based methods has opened new avenues for research and clinical application (4,5). This Research Topic serves as a testament to the dedication and ingenuity of researchers who are pushing the boundaries of this exciting field, paving the way for a future where tissue regeneration is a reality for all animals.A key theme emerging from the papers published in this Research Topic is the sustainable use of biological resources to develop cost-effective and biocompatible materials for clinical applications (6). From repurposing seafood by-products to engineering scaffolds for periodontal regeneration, researchers are pushing the boundaries of innovation while embracing principles of circular economy and environmental responsibility. The use of stem cells, whether derived from the periodontal ligament, deer antlers, or human embryonic sources, further highlights the growing potential of cell-based and …