Antibiotic residue and toxic heavy metals in aquaculture have a hazardous impact on human health and environmental
safety. So the biggest challenge is designing a powerful detecting tool without harming fsheries and the environment. A
novel dual-function silver/graphene quantum dots (Ag@GQDs)-based fuorescence nanosensor was developed to investigate
unprecedented sensing strategies for sensitive and selective detection of antibiotics and heavy metals to ensure that they are
present in the authorized percentage. Here, the fuorescence nanocomposites achieve a new successful sensitive and rapid
detection for Oxytetracycline (OTC) and Erythromycin (ERY) antibiotics with detection limits of 2.714 nM and 3.306 nM,
respectively. The proposed strategy provides an efcient detection way of tracing heavy metals Hg, Cd, and Pb with a detection limit of less than 5 ppm. Characterization of nanoprobe was by UV/VIS spectroscopy, X-ray Difraction (XRD), Fouriertransform infrared spectroscopy (FTIR), and Transmission electron microscopy (TEM). The compared results were with
graphene quantum dots (GQDs), graphene oxide quantum dots (GOQDs), and green synthesized silver nanoparticles (AgNPs)
which were made from new extracts of aquatic plants and seaweeds from Edku and Marriott Lake. This novel Fluorescence
quenching-based technique is sensitive, selective, less time-consuming and does not need expensive preparations to replace
the commonly used chromatographic detecting techniques