Marwa Elsayed Mohamed Elnagar
Asst. Professor
Association between Serum Uric Acid and Lactate Levels in Patients with Obstructive Sleep Apnea and Their Relation with Disease Severity
• 2026
Publication Information
Authors
Marwa E.Elnaggar a
, Ahmed A.Mohammed a
, Amira O.Abd El-Ghafar b
, Mai A.Ali a
Etemad A.Mohammed a
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publication.type
Local
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Abstract
Background: Obstructive sleep apnea (OSA) is the most
prevalent variation of sleep-disordered respiration. Recurrent
compression of the upper airway during sleep, which results
in oxygen desaturation and subsequent arousals from sleep, is
the hallmark of OSA. This study aimed to determine the
existence of a correlation between OSA and serum uric acid
and lactate levels as potential indicators of tissue hypoxia, as
well as their correlation with disease severity. Methods: This
prospective cross-sectional study included 50 patients with
sleep related breathing disorders who were attend at sleep
study unit, Chest department at Benha University Hospital.
Results: There was a significant positive correlation between
serum uric level after sleep and apnea–hypopnea index (AHI)
and OSA classification, lactate after sleep, Epworth sleepiness
scale (ESS),and oxygen desaturation index. There was a
significant negative correlation between serum uric level after
sleep and mean SpO2, lowest SpO2 and total sleep time. There
was a significant positive correlation between lactate level
after sleep and AHI and OSA classification, ESS and oxygen
desaturation index. There was a significant negative
correlation between lactate level after sleep and mean SpO2,
lowest SpO2 and total sleep time. The serum uric acid and
lactate after sleep was significantly higher compared to before
sleep (P
prevalent variation of sleep-disordered respiration. Recurrent
compression of the upper airway during sleep, which results
in oxygen desaturation and subsequent arousals from sleep, is
the hallmark of OSA. This study aimed to determine the
existence of a correlation between OSA and serum uric acid
and lactate levels as potential indicators of tissue hypoxia, as
well as their correlation with disease severity. Methods: This
prospective cross-sectional study included 50 patients with
sleep related breathing disorders who were attend at sleep
study unit, Chest department at Benha University Hospital.
Results: There was a significant positive correlation between
serum uric level after sleep and apnea–hypopnea index (AHI)
and OSA classification, lactate after sleep, Epworth sleepiness
scale (ESS),and oxygen desaturation index. There was a
significant negative correlation between serum uric level after
sleep and mean SpO2, lowest SpO2 and total sleep time. There
was a significant positive correlation between lactate level
after sleep and AHI and OSA classification, ESS and oxygen
desaturation index. There was a significant negative
correlation between lactate level after sleep and mean SpO2,
lowest SpO2 and total sleep time. The serum uric acid and
lactate after sleep was significantly higher compared to before
sleep (P