Marim Fayz Abdow
Asst. Professor
Protective Role of Propolis on Gentamicin nephrotoxicity of Adult Albino Rats: Histological and Immunohistochemical study
• 2024
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Marim Fayz Abdow
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Abstract
Background: Gentamicin-induced renal cortical injury is mainly contributed
to oxidative stress and other unsettled mechanisms, consequently the present
study evaluates the possible antioxidant protective role of the propolis
against this renal tubular insult in adult male rats using histological,
immunohistochemical, and morphometric analysis. Material and Methods:
45 adult male albino rats were divided into five groups (9 rats for each
group): control group, propolis treated group (Propolis group) in which the
rats received propolis in a dose of 500mg/kg orally for one month.
Gentamicin treated group (Gm group) the rats received intramuscular
injection of gentamicin in a dose of 120 mg/kg/day once daily from the 2nd
to the 7th day of the experiment then sacrificed. Gentamicin withdrawal
group (Gm withdrawal group) in which the rats injected by gentamicin as the
3rd group, but sacrificed after one month from the 1st treatment day.
Gentamicin and propolis treated group (Gm + Propolis group), the rats
treated with gentamicin as the 3rd group and received propolis in the same
dose and route of the 2nd group one-hour post gentamicin injection.
to oxidative stress and other unsettled mechanisms, consequently the present
study evaluates the possible antioxidant protective role of the propolis
against this renal tubular insult in adult male rats using histological,
immunohistochemical, and morphometric analysis. Material and Methods:
45 adult male albino rats were divided into five groups (9 rats for each
group): control group, propolis treated group (Propolis group) in which the
rats received propolis in a dose of 500mg/kg orally for one month.
Gentamicin treated group (Gm group) the rats received intramuscular
injection of gentamicin in a dose of 120 mg/kg/day once daily from the 2nd
to the 7th day of the experiment then sacrificed. Gentamicin withdrawal
group (Gm withdrawal group) in which the rats injected by gentamicin as the
3rd group, but sacrificed after one month from the 1st treatment day.
Gentamicin and propolis treated group (Gm + Propolis group), the rats
treated with gentamicin as the 3rd group and received propolis in the same
dose and route of the 2nd group one-hour post gentamicin injection.