Background: Type 2 diabetes mellitus (T2DM) and cancer, leadingglobal causes of death and disability, exhibit a notable associationinfemales, with gynecologic malignancies sharing frequent mechanismslike elevated insulin levels, IGF signaling, and dysregulatedovariansteroid hormones. This research purposed to evaluate the commonriskfactors between T2DM and women cancer and to explore thepossiblelinks between these two common diseases. Methods: Thisstudyconducted a retrospective analysis of adult females medical recordsadmitted to the Hematology and Oncology unit withintheInternalMedicine Department. The data encompassed 532 womendiagnosedwith breast, uterine, or ovarian cancer between June 2020 andJune2022.Women were divided into two groups: diabetic and non-diabetic. Foreach woman, data on age, BMI, medical history (includingDM, HTN,IHD, etc.), as well as laboratory and imaging results, was collected.Results: Breast cancer was detected in 48.1%of cases, uterinecancerin25.6%, and ovarian cancer in 26.3%. The incidence of breast anduterinecancer was notably higher during the 6th decade of life(post-menopausal) for both diabetic and non-diabetic individuals. Breast,uterine, and ovarian cancer occurrence was significantlygreaterbetween diabetic and obese patients. In the breast cancer group, theincidence of hypertension and high creatinine levels, bothassociatedwith diabetes, was higher than in the non-diabetic group. However, inuterine cancer patients, non-diabetics had a significantlyhigherIHDincidence than diabetics. However, among ovarian cancer patients,diabetic status was related to a significantly greater IHDincidence.Conclusion: T2DM women face a higher developing cancerrisk,particularly breast, uterine, and ovarian cancer. Postmenopausal DMwomen are at an elevated breast, ovarian, and uterine cancer riskandshould undergo timely screenings for these conditions