Environmental and industrial safety regulations have increased the possibilities of utilizing enzymes in textile processing to produce environmentally friendly output. An enzyme-based process was investigated to achieve bio discharge printing as an alternative to conventional chemical processes. In the current study, the enzymes polyphenol oxidase and peroxidase which extracted from potato peel (Solanum tuberosum peel) as a natural source of oxidizing agents were employed to selectively discharge printing of naturally dyed cotton and wool fabrics to impart unusual and unique effects.