محمد مصطفى محمد عبد الهادى
مدرس مساعد
Enhanced prediction of hemolytic activity in antimicrobial peptides using deep learning-based sequence analysis
BMC Bioinformatics • 2024
معلومات البحث
المؤلفون
Ibrahim Abdelbaky, Mohamed Elhakeem, Hilal Tayara , Elsayed Badr , Mustafa Abdul Salam
الكلمات المفتاحية
Antimicrobial peptide; Deep learning; Hemolytic activity; Therapeutic peptides.
المجلة العلمية
BMC Bioinformatics
الناشر
Not Available
المجلد
25
العدد
1
الصفحات
368
publication.type
International
رابط البحث
Open Link
المواد المرفقة
Not Available
الملخص
Antimicrobial peptides (AMPs) are a promising class of antimicrobial drugs due to their broad-spectrum activity against microorganisms. However, their clinical application is limited by their potential to cause hemolysis, the destruction of red blood cells. To address this issue, we propose a deep learning model based on convolutional neural networks (CNNs) for predicting the hemolytic activity of AMPs. Peptide sequences are represented using one-hot encoding, and the CNN architecture consists of multiple convolutional and fully connected layers. The model was trained on six different datasets: HemoPI-1, HemoPI-2, HemoPI-3, RNN-Hem, Hlppredfuse, and AMP-Combined, achieving Matthew's correlation coefficients of 0.9274, 0.5614, 0.6051, 0.6142, 0.8799, and 0.7484, respectively. Our model outperforms previously reported methods and can facilitate the development of novel AMPs with reduced hemolytic activity, which is crucial for their therapeutic use in treating bacterial infections.
