This study investigated the effects of dietary supplementation with the product Hilyses ongrowth performance, feed utilization, nutrient composition, hematological parameters, serumbiochemistry, immune function, antioxidant status, and digestive enzyme activity in juvenile Niletilapia (Oreochromis niloticus, initial body weight 4.24 ± 0.01 g). The fish were fed diets supplementedwith Hilyses at concentrations of 0, 1, 2, or 3 g/kg for a period of 8 weeks. The results showedthat supplementation with Hilyses at levels up to 2 g/kg diet significantly improved final bodyweight, weight gain, specific growth rate, feed efficiency ratio, protein efficiency ratio, apparentprotein utilization, and energy utilization compared to the control diet without Hilyses. Carcasscrude protein content and moisture were significantly higher in Hilyses‑fed groups, while crudelipid content decreased at the 3 g/kg supplementation level. Hilyses supplementation enhancedvarious hematological parameters, including increased red blood cell count, total leukocyte count,hemoglobin concentration, hematocrit, and mean corpuscular volume. Serum biochemistry andimmune function markers like total protein, albumin, complement component C3, IgM, and IgG weresignificantly elevated in the 2 and 3 g/kg Hilyses groups. Antioxidant enzyme activities (catalase,glutathione peroxidase, total superoxide dismutase) were enhanced, and lipid peroxidation wasreduced, in the 2 g/kg Hilyses group. Digestive enzyme activities, particularly protease and lipase,were also improved with Hilyses supplementation. Histological examination showed reduced lipiddeposition in the liver and increased branching of intestinal villi at the 2 g/kg Hilyses level. Overall,these results indicated that dietary Hilyses supplementation at 2 g/kg diet optimizes growth, feedutilization, nutrient composition, hematology, immunity, antioxidant status, and digestive function injuvenile Nile tilapia.

(15) (PDF) Effects of dietary fermented Saccharomyces cerevisiae extract (Hilyses) supplementation on growth, hematology, immunity, antioxidants, and intestinal health in Nile tilapia. Available from: https://www.researchgate.net/publication/381036685_Effects_of_dietary_fermented_Saccharomyces_cerevisiae_extract_Hilyses_supplementation_on_growth_hematology_immunity_antioxidants_and_intestinal_health_in_Nile_tilapia [accessed Jun 02 2024].