nagah.ali
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Rutin-Loaded Nanostructured Lipid Carriers Attenuate Doxorubicin-Induced Nephrotoxicity and Modulate Epigenetic Regulation and MyD88/STAT3 Signaling
• 2026
Publication Information
Authors
Amina A.Farag 1 ,WalaaBayoumie El Gazzar 2,3, Mahmoud Mostafa 4,5 Azza S. El-Demerdash 6 , Lina A. Mohammed3, , Nagah E. M. Ali 1, Ranih Z. Amer 7, Heba S. Youssef 8 Ibrahim A. Mostafa 1 , Haidy M. Fakher 1 and Sahar Soliman 9,*
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publication.type
Local
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Abstract
Doxorubicin (DOX)-induced nephrotoxicity remains a major limitation to its clinical use, yet the underlying epigenetic mechanisms are incompletely understood. This study investigated the role of epigenetic dysregulation and MyD88/STAT3 signaling in DOX-induced renal injury and evaluated the renoprotective efficacy of rutin-loaded nanostructured lipid carriers (RUT-NLCs) compared with free rutin (RUT). Thirty-six rats were allocated to six experimental groups, and renal function, oxidative stress, inflammation, DNA damage, epigenetic modifications, MyD88/STAT3 signaling, histopathology, and ultrastructural changes were assessed. D