Naglaa Hamed Ibrahim
Asst. Professor
-1(SF-Evaluating diagnostic and prognostic significance of steroidogenic factor1) and gherlin in differentiation between adrenocortical adenoma, adrenocortical carcinoma and pheochromocytoma ( immunohistochemical study)
• 2024
Publication Information
Authors
Zeinab I.Elshawarby ,Eman A.Saad ,Naglaa H.Shalan
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Abstract
Adrenal masses are a common finding in the adrenal gland. Steroidogenic factor 1 (SF1) is a nuclear transcription factor that regulates genes involved in gonadal and adrenal steroidogenesis. Ghrelin is a ligand of growth hormone secretagogue receptor type 1 (GHS-R1). The principal role of ghrelin is to regulate energy homeostasis and secretion of growth hormone.
Aim: to differentiate adrenocortical adenoma, carcinoma and pheochromocytoma immunohistochemically using stroidogenic factor-1 (SF-1) and gherlin expression and evaluate their diagnostic and prognostic significance in relation to various clinicopathologic parameters.
Material and methods: This is retrospective study carried upon 45 of different cases of adrenal gland lesions designated as: 20 cases of adrenocortical adenomas(ACA) and 10 cases of adrenocortical carcinomas(ACC) and 15 cases of pheochromocytoma . Immunohistochemical staining techniques were used to detect the role of SF-1 and gherlin in the forementioned adrenal gland lesions and evaluate their relations to different clinicopathological data and patient’s survival.
Aim: to differentiate adrenocortical adenoma, carcinoma and pheochromocytoma immunohistochemically using stroidogenic factor-1 (SF-1) and gherlin expression and evaluate their diagnostic and prognostic significance in relation to various clinicopathologic parameters.
Material and methods: This is retrospective study carried upon 45 of different cases of adrenal gland lesions designated as: 20 cases of adrenocortical adenomas(ACA) and 10 cases of adrenocortical carcinomas(ACC) and 15 cases of pheochromocytoma . Immunohistochemical staining techniques were used to detect the role of SF-1 and gherlin in the forementioned adrenal gland lesions and evaluate their relations to different clinicopathological data and patient’s survival.