Neveen Emad Ali
Dept. Head
FREQANCY OF POLYCYSTIC OVARIAN SYNDROME IN WOMEN WITH POST-ADOLESCENT ACNE
Journal of Egyptian Women's Dermatologic Society • 2014
Publication Information
Authors
Neveen Emad Sorour, lecturer of Dermatology and Andrology, Benha university. Nancy Wadeaa Michaeel, Ass. Pro. of Dermatology and Andrology, Benha university.
Keywords
Not Available
Journal
Journal of Egyptian Women's Dermatologic Society
Publisher
Wolters Kluwer
Volume
11
Issue
1
Pages
62-66
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background
Acne vulgaris in females may appear for the first time at or persist after the age of 25 years and may be resistant to treatment despite topical and systemic therapy for a sufficient period. In this condition, acne may be a manifestation of an underlying endocrine condition such as polycystic ovarian syndrome (PCOS). Objective :The aim of this study was to assess the frequency of PCOS in women with
postadolescent acne.Patients and methods: This case–control study included 40 female patients with postadolescent acne vulgaris and 20 acne-free female participants as a control group. Both patients and
controls were subjected to full assessment of history, dermatological examination, and assay of serum total testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Two of the following criteria were required for the diagnosis of PCOS: a clinical or a biochemical feature of hyperandrogenism and/or ratio of LH to FSH of at least 2 and/or ultrasonic findings of PCOS. Results: This study showed that the frequency of PCOS among postadolescent acne patients was 37.5 and 5% in the control group, with a statistically significant difference (P = 0.006). There was no statistically significant difference between the acne group
and the control group regarding serum levels of total testosterone, FSH, and LH (P = 0.23, 0.14, and 0.86, respectively). However, statistically significant difference was found between both groups in the LH/FSH ratio (P =0.033). Also, there was a highly statistically significant difference between acne patients with PCOS and those
without PCOS in the LH/FSH ratio and LH (Po0.001 for both).
Conclusion: All women with postadolescent acne should be considered for underlying PCOS. Hormonal profile and ultrasonography should be performed for patients with postadolescent acne despite the absence of menstrual irregularities or hirsutism.
Acne vulgaris in females may appear for the first time at or persist after the age of 25 years and may be resistant to treatment despite topical and systemic therapy for a sufficient period. In this condition, acne may be a manifestation of an underlying endocrine condition such as polycystic ovarian syndrome (PCOS). Objective :The aim of this study was to assess the frequency of PCOS in women with
postadolescent acne.Patients and methods: This case–control study included 40 female patients with postadolescent acne vulgaris and 20 acne-free female participants as a control group. Both patients and
controls were subjected to full assessment of history, dermatological examination, and assay of serum total testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Two of the following criteria were required for the diagnosis of PCOS: a clinical or a biochemical feature of hyperandrogenism and/or ratio of LH to FSH of at least 2 and/or ultrasonic findings of PCOS. Results: This study showed that the frequency of PCOS among postadolescent acne patients was 37.5 and 5% in the control group, with a statistically significant difference (P = 0.006). There was no statistically significant difference between the acne group
and the control group regarding serum levels of total testosterone, FSH, and LH (P = 0.23, 0.14, and 0.86, respectively). However, statistically significant difference was found between both groups in the LH/FSH ratio (P =0.033). Also, there was a highly statistically significant difference between acne patients with PCOS and those
without PCOS in the LH/FSH ratio and LH (Po0.001 for both).
Conclusion: All women with postadolescent acne should be considered for underlying PCOS. Hormonal profile and ultrasonography should be performed for patients with postadolescent acne despite the absence of menstrual irregularities or hirsutism.