Background: Dialysis is a lifesaving treatment for patients who diagnosed as kidney failure that considered as a physically stressful procedure where the majority of patients suffer from fatigue as uremic symptom after long period of dialysis sessions. Aim of the study: To evaluate effect of Intradialytic range of motion exercises program on knowledge, fatigue, and blood pressure among hemodialysis patients. A quasi-experimental research design (study & control) was utilized to achieve aim of this study. Setting: This study was conducted at Hemodialysis Unit at Benha University Hospital,Qalyubia, Governorate, Egypt. Sample: purposive sample of (80) adult patients undergoing hemodialysis were recruited in this study. Three tools were used to collect data which were Structured Interview Questionnaire, Fatigue assessment scale, Range of motion exercises Observational checklist. Results: showed that, there was high statistically significant difference in terms of high post know1edge scores of study group who were exposed to educational program than the control group. As well as, the post stable blood pressure scores of study group were improved than control group. In addition, study group exhibits low fatigue level post program implementation than control group. Conclusion: the study concluded that, intradialytic exercises program was effective in improving patient‟ knowledge, blood pressure stability, and reducing fatigue level among study group than control group .The study recommended that, Exercises schedule or planning should be involved in daily care based on patient‟s age and comorbidities under strict observation of staff . Further studies are more required to help in results generalization.