Context: Poisoning is considered as a major cause of morbidity and mortality worldwide as
patients admitted to hospital in a critical condition to save their life as soon as possible regardless of
the type and quantity of the poison. Study aim: To evaluate the effect of educational guidelines
about the first 24-hour nursing interventions for poisoning patients on nurses’ performance and
patient’s health outcomes. Methods: A quasi-experimental research design (pre/post test) was used.
Setting: Study was conducted in poisoning control center at Benha university hospital, Qualyubia,
Egypt. Sample: A convenience sample of (200) patients and (41) nurses were recruited in this
study. Tools: Four tools were used; (I) Self-administered nurses’ knowledge questionnaire, (II)
nurses’ practice observational checklist (III) nurses’ attitude questionnaire, (IV) patient’ health
outcomes assessment questionnaire. Results: There was highly statistically significant improvement
in total mean score of nurses’ knowledge, practice, and attitude regarding care of poisoning patients
within the first 24 hours throughout post guidelines implementation observed as p