Omnia Youssef
Professor
Significance of expression of PD-L1, VEGF and CD8+ T cells in ovarian serous carcinoma: an Immunohistochemical study
Benha medical journal. • 2023
Publication Information
Authors
Omneya Y. Bassyoni a, Ebtehal M. Abdel Aal a , Ahmed Khalil
Keywords
PD-L1, VEGF and CD8+T cells.
Journal
Benha medical journal.
Publisher
Benha University, Faculty of Medicine
Volume
vol. 40
Issue
issue 3
Pages
745-758
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Ovarian cancer is a lethal gynecological
malignancy worldwide. The immune system plays a key role in
preventing tumor development. Angiogenesis and immune
evasion are vital for ovarian cancer progression and metastasis.
Aim: This work aimed to evaluate the expression of PD-L1,
VEGF and CD8 +T cells in ovarian serous carcinomas and
correlate them with clinic-pathological variables. Material and
methods: An Immunohistochemical study of PD-L1, VEGF and
CD8+ T cells was performed on 50 cases of ovarian serous
carcinomas. Results: PD-L1 & VEGF were over-expressed with
statistical significance , in higher grade (P
malignancy worldwide. The immune system plays a key role in
preventing tumor development. Angiogenesis and immune
evasion are vital for ovarian cancer progression and metastasis.
Aim: This work aimed to evaluate the expression of PD-L1,
VEGF and CD8 +T cells in ovarian serous carcinomas and
correlate them with clinic-pathological variables. Material and
methods: An Immunohistochemical study of PD-L1, VEGF and
CD8+ T cells was performed on 50 cases of ovarian serous
carcinomas. Results: PD-L1 & VEGF were over-expressed with
statistical significance , in higher grade (P