Background: Papillary breast neoplasms are heterogenous
group of breast diseases consisting of wide range of benign,
atypical and malignant lesions. Evaluation of such papillary
neoplasms is considered one of the most problematic issues
in diagnosis of breast pathology depending on H&E only as
they need different interventional treatment modalities. Aim
of study: To differentiate papillary breast lesions depending
on immunohistochemical staining of P63, SMA, CK14,
chromogranin and ER. Materials and Methods: An
Immunohistochemical study of P63, SMA, CK14,
chromogranin and ER were conducted on 75 cases of
different papillary breast neoplasms; papilloma (20 cases ) ,
DCIS ( 25 cases ) , solid papillary carcinoma ( 12 cases ),
intracystic papillary carcinoma ( 11cases) and invasive
micropapillary carcinoma (7 cases) . Results: Out of 75
cases, all cases of duct papillomas were positive to SMA,
P63. Ninety percent (90 %) of them were positive to CK14
in comparison to malignant papillary: DCIS, intracystic
papillary carcinomas. solid papillary carcinomas neoplasms
which were negative (84.0%, 92.3 %, 90.0% & 100.0%,
respectively). Ninety -two percentage (92 %) of DCIS cases,
92.3% intracystic papillary carcinomas, 90.0% solid papillary
carcinomas and all cases of invasive micropapillary
carcinomas- showed homogenous positivity for ER compared to papillomas that
showed focal heterogenous expression with statistical significant (p