Omnia Youssef
Professor
The Role Of IMP3 And BCL2 In Differentiating Between Irritated Seborrheic Keratosis, Insitu And Invasive Squamous Cell Carcinomas Of The Skin
Benha medical journal • 2021
Publication Information
Authors
Omneya Y. Bassyoni, Nashwa M. Emara, Heba M. Rashad
Keywords
irritated seborrheic keratosis, squamous cell carcinoma, IMP3, BCL2
Journal
Benha medical journal
Publisher
Benha University, Faculty of Medicine
Volume
Volume 39
Issue
Not Available
Pages
210-219
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Introduction: The histological distinction between squamous cell
carcinoma both in-situ and invasive from their benign mimic; irritated
seborrheic keratosis is still a difficulty. The aim of this study is to
investigate the diagnostic utility of Insulin-like growth factor II
mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 )
in differentiating aforementioned cutaneous tumors. Materials and
Methods: This is a retrospective study to include 50 cases, 25(50%)
cases of invasive squamous cell carcinoma (SCC), 10 (20%) cases of
squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of
irritated seborrheic keratosis (ISK). The immunohistochemical
expression of IMP3 and BCL2 was studied (9) Results: BCL2 was
expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in
SCCIS and 4/25 (16%) in invasive SCC cases (p
carcinoma both in-situ and invasive from their benign mimic; irritated
seborrheic keratosis is still a difficulty. The aim of this study is to
investigate the diagnostic utility of Insulin-like growth factor II
mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 )
in differentiating aforementioned cutaneous tumors. Materials and
Methods: This is a retrospective study to include 50 cases, 25(50%)
cases of invasive squamous cell carcinoma (SCC), 10 (20%) cases of
squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of
irritated seborrheic keratosis (ISK). The immunohistochemical
expression of IMP3 and BCL2 was studied (9) Results: BCL2 was
expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in
SCCIS and 4/25 (16%) in invasive SCC cases (p