Background: Lung cancer is the most common type of
cancer and the principal cause of death from cancer
worldwide. This study aimed to evaluate the expression
of Napsin A and CK5/6 in NSCLC, correlate
immunohistochemical results of Napsin A and CK5/6 in
differentiating between adenocarcinoma and SCC of the
lung. assessment of the expression pattern of Napsin A
and CK 5/6 as regards the available clinicopathological
data available. Methods: This retrospective study was
carried out on 40 lung cases; included 26 adenocarcinoma
cases (Resection) and 14 cases of squamous cell carcinoma
(Including 7 resection cases and 7 bronchoscopic biopsy
cases). Results: Highly significant increase in CK5/6 score
and expression, in SSC group; compared to ADC group (p
< 0.001). ADC had a highly significant positive correlation
with Napsin A score (p < 0.01). In the current study
Pearson’s correlation analysis shows that SSC, had a
highly significant positive correlation with CK5/6 score.
Conclusion: From our findings we can conclude that
Napsin A score can predict patients with ADC from
patients with SSC. the increase in SSC histology; had an independent effect on increasing
the probability of CK5/6 expression. The decrease in LN; had an independent effect on
increasing the probability of Napsin A expression.