9Brodifacoum is a 4-hydroxycoumarin anticoagulant rodenticide of Rodents widely used and contaminating food items. Ginger (Zingiber officinale) widely used medicinal plant an antioxidant and preventing agent against numbers of diseases. The study deals with Illustrating the effects of brodifacoum on the chromosomal structure, as well as the histopathological structures of liver and testis of male mice and the protective effects role of ginger extract. 130 Adult albino male mice were used in this study. Group (G1) served as control. Groups (G 2 and 3) were received ginger extract doses 1.5% and 3%. Groups (G 4 and 5) received single dose (1/10 LD50) of brodifacoum for group (G 4) and (1/20 LD50) for group (G 5). Groups (G6, 7, 8, and 9) received brodifacoum then ginger extract. Groups (G10, 11, 12 and 13) received ginger extract then brodifacoum. Animals from all the groups were sacrificed and their bone marrow cells were analysed for chromosomal damage. Liver and testis samples are separated for histopathological examination. The animals, brodifacoum-treated group showed significant increase of chromosomal aberrations and the value of mitotic index were reduced. Treated male mice with brodifacoum induced various histological changes in liver and testis. Treated animals with brodifacoum and ginger lead to reduction in chromosomal aberrations, significant increase in mitotic index and slight improvement in the histological change in liver and testis. Results obtained from this study demonstrated that brodifacoum has a mutagenic effect on chromosome and histopathological change in different organ (liver and testis) and the use of ginger may be a potent protective against the toxicity of brodifacoum anticoagulant rodenticide.