Caregivers play a vital role in providing comprehensive care for children with cerebral palsy, as they practices greatly enhance effectiveness of hyperbaric oxygen therapy and prevent its complications. Aim of study: This study aimed to evaluate the effectiveness of a video-assisted teaching program for caregivers regarding caring of children with cerebral palsy. Research design: This study used a quasi-experimental research design. Setting: This study was carried out at the Hyperbaric Oxygen Therapy Unit in the Nasser Institute for Research and Treatment, Cairo, Egypt. Sample: 76 caregivers and their children (divided into study and control groups) were taken by a purposive sample. Tools of data collection: Five tools were used. 1): A structured interviewing questionnaire sheet, which consisted of three parts A) Socio-demographic traits of caregivers under the study and personal data of children with cerebral palsy. B) Medical data of the children with cerebral palsy. C) Knowledge of the studied caregivers regarding cerebral palsy and hyperbaric oxygen therapy. II) The FLACC pain scale. III) Checklist to assess caregivers practices. IV) Communication function classification system scale V) Communication and symbolic behavior scales Results: The findings revealed that the mean ages of caregivers under the study were 33.03±4.750 and 32.42±5.006 years, respectively. 18.4% and 15.8% of the study and control groups of caregivers had good total knowledge level pre-program implementation, improved to 81.6% and 28.9% post program implementation, respectively. Also, a highly statistically significant positive correlation between total practices of studied caregivers and communication abilities of their children with cerebral palsy was present then control group