Background
Helicobacter pylori has been known as the strongest risk factor in developing
gastric carcinoma (GC) through a cascade of epithelial changes that lead to
precancerous lesions, which predispose to GC.
Aim
This study was designed to investigate the expression of P53, SOX2, and SOX9 in
H. pylori chronic gastritis, precancerous gastric lesions, and GC.
Patients and methods
A total of 57 cases of chronic gastritis were selected [37 cases of chronic superficial
gastritis without intestinal metaplasia (IM) and 20 cases showed IM], 18 cases of
dysplasia, and 30 cases of GC, besides six normal gastric endoscopic biopsies.
Giemsa stains were used to detect H. pylori colonies. Immunohistochemical
technique was applied to detect P53, SOX2, and SOX9 expression and
correlate them with clinicopathological finding.
Results
Both P53 and SOX9 expressions were statistically increased from normal gastric
mucosa through chronic superficial gastritis, IM, dysplastic cases, and GC. In
contrast, SOX2 expression was observed in 9.5% of GC, compared with 83.3% of
normal mucosa.
Among H. pylori-infected cases, P53 expression was found in 53.8% of chronic
superficial gastritis, 81.2% of metaplasia, 88.8% of dysplasia, and 80% of GC cases
(P