Rasha Mahmoud Abdrabh Mahmoud
Asst. Professor
Significance of Ubiquitin-Conjugating Enzyme (UBE2C) and P53 Expression in Molecular Subtypes of Breast Carcinoma; An Immunohistochemical Study
• 2024
Publication Information
Authors
Rasha M. Abd-Rabh, Sara G. Masoud, Ragaey R. Fahmy,Abdellatif M. Elbalshy
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publication.type
Local
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Abstract
Background: Breast cancer (BC) is the most common
malignant tumor in females worldwide. It is categorized into
four main molecular subtypes. Ubiquitin-conjugating
enzyme (UBE2C) is essential for the ubiquitin–proteasome
system which regulates checkpoints in the cell cycle.
Dysregulation of ubiquitination has been associated with
different types of cancer. P53 is important tumor suppressor
gene. In some cancers mutant p53 proteins not only lose
tumor suppressive functions, but also acquire oncogenic
activity. Aim: This study aims at evaluation of UBE2C and
P53 expression in molecular subtypes of breast cancer and
assessment of their role in pathogenesis and tumor
progression. Materials and methods: This controlled
retrospective study included selected 50 cases of breast
cancer mastectomy specimens. UBE2C and P53
immunostaining were performed for all cases. Results:
UBE2C expression showed highly significant statistical
association with tumor stage (P
malignant tumor in females worldwide. It is categorized into
four main molecular subtypes. Ubiquitin-conjugating
enzyme (UBE2C) is essential for the ubiquitin–proteasome
system which regulates checkpoints in the cell cycle.
Dysregulation of ubiquitination has been associated with
different types of cancer. P53 is important tumor suppressor
gene. In some cancers mutant p53 proteins not only lose
tumor suppressive functions, but also acquire oncogenic
activity. Aim: This study aims at evaluation of UBE2C and
P53 expression in molecular subtypes of breast cancer and
assessment of their role in pathogenesis and tumor
progression. Materials and methods: This controlled
retrospective study included selected 50 cases of breast
cancer mastectomy specimens. UBE2C and P53
immunostaining were performed for all cases. Results:
UBE2C expression showed highly significant statistical
association with tumor stage (P