Background: High-alert medications are most likely to significantly harm the children when
improperly used as, the consequence of an error with these medications are significantly worse for
children. So, nurses should be aware about dealing with these medications safely. The study aim was
to evaluate the effect of educational guidelines on nurses’ performance about safe use of high alert
medications at pediatric intensive care units. Study design: A quasi- experimental approach with pre
and post intervention. Sample: A convenient sample of all available nurses (n=66) and purposive
sample of children (n=66) at Pediatric Intensive Care Units in Benha University Hospital and Benha
Specialized Pediatric Hospital. Tools of data collection: Tool (I): A structured interviewing
questionnaire sheet: It consisted of Part A: Personal characteristics of studied sample that include: 1- The
studied nurses, 2- Children, Part B: Nurses’ knowledge regarding safe use of high alert medications. Tool
II: An Observational Checklist used to assess nurses’ practice about safe use of high alert medications. Tool
III: Likert scale for nurses' attitude regarding safe use of high alert medications in children. Result: There
was a highly statistically significance of studied nurses’ knowledge, practice and attitude regarding safe use
of high alert medications in PICU at pre and post educational guidelines phases (p