Reda ibrahim ahmed El kammar
Asst. Professor
Synergistic protective effects of lycopene and N acetylcysteine against cisplatin‑induced hepatorenal toxicity in rats.
Scientific Reports • 2021
Publication Information
Authors
Asmaa Elsayed; Ashraf Elkomy; Reda Elkammar; GehanYoussef; EhabYahya Abdelhiee; Walied Abdo; Sabreen Ezzat Fadl; Ahmed Soliman; Mohamed Aboubakr.
Keywords
Not Available
Journal
Scientific Reports
Publisher
Not Available
Volume
11
Issue
Not Available
Pages
13979
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Cisplatin (CP) is one of the most frequently used chemotherapy agents. The objective of this design
was to determine the ameliorative effect of lycopene (LP) and/or N‑acetylcysteine (NAC) in rats
with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats/
group): control vehicle group (saline only), the LP group (10 mg/kg, orally), the NAC group (150 mg/
kg, orally), the CP group (7.5 mg/kg, IP on day 27), the LP‑CP group, the NAC‑CP group, and the
LP‑NAC‑CP group. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST),
and alkaline phosphatase (APK), and levels of urea, creatinine, and lipids (cholesterol, triglycerides,
and low‑density lipoprotein‑cholesterol) increased after CP injection in the serum. Moreover, CP
decreased levels of protein, albumin, and HDL cholesterol. Meanwhile, malondialdehyde significantly
increased with a decrease in reduced glutathione, superoxide dismutase, and catalase in the liver and
kidney tissues. CP also induced some pathological lesions and increased the expression of caspase‑3
in the liver and kidney tissues. Administration of LP and NAC alone or in combinations ameliorated
hepatorenal toxicity and apoptosis induced by CP.
was to determine the ameliorative effect of lycopene (LP) and/or N‑acetylcysteine (NAC) in rats
with hepatic and renal toxicity induced by CP. Rats were divided randomly into 7 groups (7 rats/
group): control vehicle group (saline only), the LP group (10 mg/kg, orally), the NAC group (150 mg/
kg, orally), the CP group (7.5 mg/kg, IP on day 27), the LP‑CP group, the NAC‑CP group, and the
LP‑NAC‑CP group. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST),
and alkaline phosphatase (APK), and levels of urea, creatinine, and lipids (cholesterol, triglycerides,
and low‑density lipoprotein‑cholesterol) increased after CP injection in the serum. Moreover, CP
decreased levels of protein, albumin, and HDL cholesterol. Meanwhile, malondialdehyde significantly
increased with a decrease in reduced glutathione, superoxide dismutase, and catalase in the liver and
kidney tissues. CP also induced some pathological lesions and increased the expression of caspase‑3
in the liver and kidney tissues. Administration of LP and NAC alone or in combinations ameliorated
hepatorenal toxicity and apoptosis induced by CP.