Reda ibrahim ahmed El kammar
Asst. Professor
Ameliorating Effect of Lycopene and N-Acetylcysteine against Cisplatin-Induced Cardiac Injury in Rats
Pak Vet J • 2022
Publication Information
Authors
Asmaa Elsayed1, Ashraf Elkomy1, Mohamed Alkafafy2, Reda Elkammar3, Sabreen Ezzat Fadl4, Ehab Yahya Abdelhiee5,
Ahmed Abdeen6, Gehan Youssef6, Hassan Shaheen7, Ahmed Soliman8 and Mohamed Aboubakr
Keywords
Cardiac toxicity
Caspase-3
Cisplatin
Lycopene
N acetylcysteine
Rats
Journal
Pak Vet J
Publisher
Not Available
Volume
42(1)
Issue
Not Available
Pages
107-111
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer
activities. This research investigated the possible protective effects of lycopene
(LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven
groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg,
PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the
experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following
injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase
(LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in
serum of the treated groups. In addition, CP resulted in a significant increase in
malondialdehyde (MDA), as well as significant decreases in glutathione (GSH),
superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in
changes in cardiac histopathology and increased caspase-3 expression in cardiac
tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and
apoptosis induced by CP, through their antioxidant properties.
activities. This research investigated the possible protective effects of lycopene
(LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven
groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg,
PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the
experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following
injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase
(LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in
serum of the treated groups. In addition, CP resulted in a significant increase in
malondialdehyde (MDA), as well as significant decreases in glutathione (GSH),
superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in
changes in cardiac histopathology and increased caspase-3 expression in cardiac
tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and
apoptosis induced by CP, through their antioxidant properties.