Safwa Mahmoud Soror
Dept. Head
Alchemilla vulgaris modulates isoproterenol-induced cardiotoxicity: interplay of oxidative stress, inflammation, autophagy, and apoptosis
• 2024
Publication Information
Authors
Nuha Anajirih1, Ahmed Abdeen2*, Ehab S. Taher3,
Afaf Abdelkader4, Hoda A. Abd-Ellatieff5, Mahmoud S. Gewaily6,
Nashwa E. Ahmed7, Rasha H. Al-Serwi8, Safwa M. Sorour9
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publication.type
International
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Abstract
Isoproterenol (ISO) is regarded as an adrenergic non-selective β
agonist. It regulates myocardial contractility and may cause damage to cardiac
tissues. Alchemilla vulgaris (AV) is an herbal plant that has garnered considerable
attention due to its anti-inflammatory and antioxidant bioactive components. The
present investigation assessed the cardioprotective potential of AV towards ISOinduced
myocardial damage.
Methods: Four groups of mice were utilized: control that received saline, an ISO
group (85 mg/kg, S.C.), ISO + AV100, and ISO + AV200 groups (mice received 100
or 200 mg/kg AV orally along with ISO).
agonist. It regulates myocardial contractility and may cause damage to cardiac
tissues. Alchemilla vulgaris (AV) is an herbal plant that has garnered considerable
attention due to its anti-inflammatory and antioxidant bioactive components. The
present investigation assessed the cardioprotective potential of AV towards ISOinduced
myocardial damage.
Methods: Four groups of mice were utilized: control that received saline, an ISO
group (85 mg/kg, S.C.), ISO + AV100, and ISO + AV200 groups (mice received 100
or 200 mg/kg AV orally along with ISO).