Salwa Ali Zein El Abedeen
Asst. Professor
Arthrospira platensis Nanoparticles Mitigate Aging-Related Oxidative Injured Brain Induced by D-galactose in Rats Through Antioxidants, Anti- Inflammatory, and MAPK Pathways
• 2023
Publication Information
Authors
Heba I Ghamry1,*, Mustafa Shukry 2,*, Mohamed A Kassab3, Foad A Farrag4, Nagi M El-Shafai5, Enas Elgendy6,
Amany N Ibrahim7, Salwa A Elgendy7
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publication.type
International
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Abstract
Loss of normal function is an inevitable effect of aging. Several factors contribute to the aging process, including
cellular senescence and oxidative stress.
Methods: We investigate how Arthrospira platensis Nanoparticles (NSP) protect against aging injury induced by d-galactose (D-gal)
in the rat. So, we subcutaneously (S/C) injected D-gal at 200 mg/kg BW to see if Arthrospira platensis Nanoparticles (NSP) might
protect against the oxidative changes generated by D-gal. NSP (0.5 mg/kg body weight once daily by gastric gavage) was given to all
groups apart from the control and D-gal groups. The d-gal + NSP group was supplemented with 200 mg of D-gal per kg BW once
a day and NSP 0.5 mg/kg BW given orally for 45 days. Biochemical, mRNA expression, and histological investigations of brain
tissues were used to evaluate the oxidative alterations caused by d-gal and the protective role of NSP.
cellular senescence and oxidative stress.
Methods: We investigate how Arthrospira platensis Nanoparticles (NSP) protect against aging injury induced by d-galactose (D-gal)
in the rat. So, we subcutaneously (S/C) injected D-gal at 200 mg/kg BW to see if Arthrospira platensis Nanoparticles (NSP) might
protect against the oxidative changes generated by D-gal. NSP (0.5 mg/kg body weight once daily by gastric gavage) was given to all
groups apart from the control and D-gal groups. The d-gal + NSP group was supplemented with 200 mg of D-gal per kg BW once
a day and NSP 0.5 mg/kg BW given orally for 45 days. Biochemical, mRNA expression, and histological investigations of brain
tissues were used to evaluate the oxidative alterations caused by d-gal and the protective role of NSP.