This study investigated the results of using dietary supplements with glycerol monolaurate (GML) and lysoforte (LFT) on broiler chickens' serum biochemistry, nutrient digestibility, and liver morphology. A 35-day trial was conducted using 240 newly hatched avian Cobb broiler chicks, divided into four dietary treatments at random: 1) a basic control diet (CON), 2) basal diet with 0.025% Lysoforte, 3) basal diet with 0.05% Glycerol monolaurate, and 4) a combination of 0.05% Glycerol monolaurate + 0.025% Lysoforte. Each treatment included 4 replicates with 15 chicks per replicate. The results showed no significant changes in liver enzyme activity (AST, ALT, ALP), total protein, albumin levels, or indicators of kidney function (creatinine, urea, and uric acid) among treatment groups, compared to the control. Serum lipid profiles remained largely unaffected, except for increased HDL-cholesterol in birds fed diets containing GML and LFT. Serum glucose concentration significantly decreased with GML supplementation. While dry matter digestibility was not influenced, fat digestibility improved with LFT and GML supplementation. Histological examination revealed normal and healthy liver structures across all treatment groups. These findings suggest that dietary GML and LFT enhance fat utilization without adverse effects on liver or kidney functions, offering potential benefits for broiler production.