Shereen Abd Alfatah Ebrahim Algergawy
Professor
Urinary Angiostatin As Alternative To Biopsy In Lupus Nephritis Patients Among Egyptian. Algergawy1, Shereen, Alshaar2, Osama, Zakaria3, Rania
Arthritis & Rheumatism, Volume 65, October 2013 Abstract Supplement • 2013
Publication Information
Authors
Algergawy1, Shereen, Alshaar2, Osama, Zakaria3, Rania
Keywords
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Journal
Arthritis & Rheumatism, Volume 65, October 2013 Abstract Supplement
Publisher
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Volume
volum 65
Issue
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Pages
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publication.type
International
Paper Link
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Supplementary Materials
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Abstract
Background/Purpose:
Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains the basis of LN diagnosis. There is urgent need to identify biomarkers that alternative to renal pathology in lupus.
Aim: To study urinary angiostatin in SLE and investigate their possible role as indicative of renal involvement to be used as alternative to biopsy.
Methods:
Angiostatin levels were measured in urine samples from 45 lupus patients and 14 healthy volunteers, renal biopsy was obtained from all patients
Results:
SLE patients had elevated urinary angiostatin as compared to controls (P < 0.001). Levels of urinary angiostatin were higher in patients with an active LN (lupus nephritis) than those with inactive LN (P < 0.001). In patients with LN urinary angiostatin correlated with the renal score of the Systemic Lupus Erythematosus Disease Activity Index. Urinary angiostatin levels varied significantly and there is significant positive correlation (P
Lupus nephritis (LN) is one of the most frequent manifestations of SLE and can be present in 60% of SLE patients. Kidney biopsy remains the basis of LN diagnosis. There is urgent need to identify biomarkers that alternative to renal pathology in lupus.
Aim: To study urinary angiostatin in SLE and investigate their possible role as indicative of renal involvement to be used as alternative to biopsy.
Methods:
Angiostatin levels were measured in urine samples from 45 lupus patients and 14 healthy volunteers, renal biopsy was obtained from all patients
Results:
SLE patients had elevated urinary angiostatin as compared to controls (P < 0.001). Levels of urinary angiostatin were higher in patients with an active LN (lupus nephritis) than those with inactive LN (P < 0.001). In patients with LN urinary angiostatin correlated with the renal score of the Systemic Lupus Erythematosus Disease Activity Index. Urinary angiostatin levels varied significantly and there is significant positive correlation (P