Background: It was estimated that 15 million preterm neonates were born worldwide each
year, with over one million of those neonates dying as a result of prematurity. The aim of
developmental supportive care is to create a womb out of womb which improve comfort of the
preterm neonates in the Neonatal Intensive Care Unit. Aim of this study was to assess the effect of
simulative heartbeat nest on improving physiological parameters, comfort and pain of preterm
neonates at neonatal intensive care unit. Research design: A quasi experimental design was utilized
in this study. Setting: This study was conducted at neonatal intensive care unit in Specialized
Pediatric Hospital at Benha City. Subjects: Purposive sample of preterm neonates (60) at neonatal
intensive care was involved. Tools of data collection Tool (I): A structured interviewing
questionnaire: It included three parts: Part (1): Personal characteristics of the studied preterm
neonates. Part (2): Physical parameters of preterm neonates. Part (3): Physiological measurements
of the studied preterm neonates. Tool (II): Premature baby comfort scale. Tool (III): Premature baby
pain profile (PIPP-R). Results: There were a highly statistically significant difference (P-value