Yousef Mohamed Abdelzaher Ali
Asst. Professor
TheRelationbetweenDeregulatedImmuneMilieuandAtherogenic Lipids Might Underlie the Development of Pregnancy-induced Hypertensive Disorders
evidence based women's health • 2023
Publication Information
Authors
Youssef Abdel Zaher, Ibrahiem M Rageh and Ali A. Morsy
Keywords
Early prediction, lipoprotein (a), preeclampsia, tumor Necrosis Factor-α.
Journal
evidence based women's health
Publisher
Evidence Based Women’s Health Society
Volume
13
Issue
1
Pages
68-75
publication.type
Local
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Objectives: Evaluation of the relation between plasma lipoprotein(a) (LPA) and serum tumor necrosis factor-α (TNF-α)
levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of
preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time).
Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed
early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54
women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all
patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples.
Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE
than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed
LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028),
high S1 levels of TNF-α (β=0.424, P
levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of
preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time).
Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed
early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54
women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all
patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples.
Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE
than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed
LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028),
high S1 levels of TNF-α (β=0.424, P