سارة متولى عبدالله محمد عبدالسيد
مدرس
Citrate-capped AuNPs-induced redox reprogramming modulates the TP53–BAX/BCL2–CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy • 2026
معلومات البحث
المؤلفون
A Elmetwalli; Sara Abdelsayed; M G Hassan; Ibtisam Aboud Almutairi; Deema Kamal Sabir; Hassnaa Elsherbiny; Ashraf Elsayed
الكلمات المفتاحية
Gold nanoparticles; Hepatocellular carcinoma; TP53; Apoptosis; Redox reprogramming
المجلة العلمية
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
الناشر
Elsevier
المجلد
344
العدد
Part 1
الصفحات
126630
publication.type
International
رابط البحث
Open Link
المواد المرفقة
Not Available
الملخص
Gold nanoparticles (AuNPs) capped with citrate were assessed for selective cytotoxicity in HepG2 liver cancer cells compared to normal fibroblasts. AuNPs induced redox reprogramming, affecting TP53, BAX, BCL2, and CASP3 expression, disrupted mitochondrial membrane potential, and enhanced antioxidant defense, leading to apoptosis. These findings suggest potential nanomedicine strategies targeting cancer cell vulnerabilities